Beleaguered Everton have been relegated to the Championship, but the Blues are one of three Premier League sides to have won the Champions League and Europa League this season.
Besiktas’ victory over Atletico Madrid on Sunday earned them first place in Group B, while Manchester City, with a draw, will be looking to avoid a repeat of their 4-0 defeat to Swansea City in the FA Cup final last month.
Meanwhile, Newcastle United will be back in the Premier League with a trip to Crystal Palace on Tuesday, with the Magpies currently sitting second in the table.
Coventry City and Sheffield United will also be on a short break, with Coventry playing a game in the Championship on Saturday and Sheffield coming to Turf Moor on Tuesday.
Newcastle will also play Aston Villa in the League Cup on Tuesday evening, with Villa having won their previous four Premier League games against Newcastle.
Arsenal will be without captain Alexis Sanchez and striker Alexis Sanchez Sanchez will be unavailable for the clash against Crystal Palace.
Elsewhere, Liverpool will be in the Europa League, having lost their first two matches of the season.
The Reds will play Real Madrid in a match to decide the Europa Trophy at Wembley on Saturday.
Sunderland will be playing Hull City in a Europa League first leg on Tuesday afternoon.
Liverpool and Stoke City will both be in League Cup action on Wednesday, with Stoke playing Hull and Liverpool playing Burnley in the third round.
Watford will be facing Aston Villa on Tuesday in the first round of the FA Super Cup.
The FA Cup is a semi-finals stage of the competition, with teams from the Premier and Championship sides playing each other in the semi-final.
On Tuesday, the FA Trophy will be played in Cardiff with a kick-off at 4pm.
Wednesday’s fixture will be broadcast live on Sky Sports Premier League, with highlights on BT Sport 2HD.